DQ661

DQ661 is a potent PPT1 inhibitor. DQ661 is a dimeric quinacrine autophagy inhibitor. DQ661 inhibits mTORC1 activity. DQ661 decreases the protein expression of pS6K T389, pS6 S240-244. DQ661 shows anticancer activity[1][2].

Product Specifications

CAS Number

[2027551-01-3]

UNSPSC

12352005

Target

Autophagy; mTOR

Related Pathways

Autophagy; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

ClC(C=CC1=C2NCCCCCCN(CCCCCCNC3=C4C=CC(Cl)=CC4=NC5=C3C=C(OC)C=C5)C)=CC1=NC6=C2C=C(OC)C=C6

Molecular Formula

C41H47Cl2N5O2

Molecular Weight

712.75

References & Citations

[1]Nicastri MC, et al. Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells. Mol Cell Oncol. 2017 Nov 30;5 (1) :e1395504.|[2]Rebecca VW, et al. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 Nov;7 (11) :1266-1283.