PROTAC XPO1 degrader-1
PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. PROTAC XPO1 degrader-1 exhibits anti-proliferative effects, can induce cell apoptosis, inhibit NF-κB activity, and cause cell cycle arrest in the G1 phase. PROTAC XPO1 degrader-1 can be used in research on hematological malignancies (Pink: Target Protein Ligand (HY-170672) ; Black: Linker (HY-W010525) ; Blue: E3 Ligase Ligand (HY-170671) ; E3 Ligase Ligand-Linker Conjugate (HY-170673) ) [1].
Product Specifications
CAS Number
[3105680-00-7]
UNSPSC
12352005
Target
Apoptosis; CRM1; NF-κB; PROTACs
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C(F)(F)F)C=CC(NN2C(C(C)=C(CCC(NCC3CCN(C4=CC=C(C(NC5C(NC(CC5)=O)=O)=O)C(OC)=C4)CC3)=O)C2=O)=O)=N1
Molecular Formula
C33H35ClF3N7O7
Molecular Weight
734.12
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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