PROTAC XPO1 degrader-1

PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. PROTAC XPO1 degrader-1 exhibits anti-proliferative effects, can induce cell apoptosis, inhibit NF-κB activity, and cause cell cycle arrest in the G1 phase. PROTAC XPO1 degrader-1 can be used in research on hematological malignancies (Pink: Target Protein Ligand (HY-170672) ; Black: Linker (HY-W010525) ; Blue: E3 Ligase Ligand (HY-170671) ; E3 Ligase Ligand-Linker Conjugate (HY-170673) ) [1].

Product Specifications

CAS Number

[3105680-00-7]

UNSPSC

12352005

Target

Apoptosis; CRM1; NF-κB; PROTACs

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; NF-κB; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=C(C(F)(F)F)C=CC(NN2C(C(C)=C(CCC(NCC3CCN(C4=CC=C(C(NC5C(NC(CC5)=O)=O)=O)C(OC)=C4)CC3)=O)C2=O)=O)=N1

Molecular Formula

C33H35ClF3N7O7

Molecular Weight

734.12

References & Citations

[1]Chen G, et al. Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia[J]. European Journal of Medicinal Chemistry, 2025, 283: 117182.