EGFR T790M/L858R-IN-9
EGFR T790M/L858R-IN-9 (Compound 8) is an EGFR-L858R/T790M inhibitor that demonstrates potent inhibitory phosphorylation effects against the EGFR-L858R/T790M mutant kinase, with an IC50 value of 0.0064µM. EGFR T790M/L858R-IN-9 also inhibits the proliferation of non-small cell lung cancer (NSCLC) cells and can be utilized in cancer research[1].
Product Specifications
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC=C(C2=NN=C(NC3=NC(OC4=CC(N5CCN(C(CC)=O)CC5)=CC=C4)=NC=C3)S2)C=C1
Molecular Formula
C26H27N7O3S
Molecular Weight
517.60
References & Citations
[1]Ahmad I, et al. Design, Synthesis, and Evaluation of Novel 2, 4‐disubstituted Pyrimidine Derivatives as Double Mutant Epidermal Growth Factor Receptor‐L858R/T790M Tyrosine Kinase Inhibitors[J]. Journal of Biochemical and Molecular Toxicology, 2025, 39 (1) : e70077.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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