EGFR T790M/L858R-IN-9

EGFR T790M/L858R-IN-9 (Compound 8) is an EGFR-L858R/T790M inhibitor that demonstrates potent inhibitory phosphorylation effects against the EGFR-L858R/T790M mutant kinase, with an IC50 value of 0.0064µM. EGFR T790M/L858R-IN-9 also inhibits the proliferation of non-small cell lung cancer (NSCLC) cells and can be utilized in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=CC=C(C2=NN=C(NC3=NC(OC4=CC(N5CCN(C(CC)=O)CC5)=CC=C4)=NC=C3)S2)C=C1

Molecular Formula

C26H27N7O3S

Molecular Weight

517.60

References & Citations

[1]Ahmad I, et al. Design, Synthesis, and Evaluation of Novel 2, 4‐disubstituted Pyrimidine Derivatives as Double Mutant Epidermal Growth Factor Receptor‐L858R/T790M Tyrosine Kinase Inhibitors[J]. Journal of Biochemical and Molecular Toxicology, 2025, 39 (1) : e70077.