NF-κB-IN-18
NF-κB-IN-18 (Compound 5k) is an orally active NF-κB inhibitor. NF-κB-IN-18 inhibits phosphorylation of p65. NF-κB-IN-18 exhibits potent anti-inflammatory activity in Xylene-induced ear edema mice[1].
Product Specifications
UNSPSC
12352005
Target
NF-κB
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C(COC1=C(C(OC)=O)C(OC(C)(C)C=C2)=C2C3=C1C=CC(C)(C)O3)NC4=CC=C5C(C=CC=N5)=C4
Molecular Formula
C29H28N2O6
Molecular Weight
500.54
References & Citations
[1]Gao YL, et al. Mollugin Derivatives as Anti-Inflammatory Agents: Design, Synthesis, and NF-κB Inhibition. Chem Biol Drug Des. 2024 Dec;104 (6) :e70024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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