AChE-IN-80

AChE-IN-80 (Compound 1) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-80 can inhibit inflammation and the production of reactive oxygen species (ROS) in vitro- cultured neurons and microglia, trigger autophagy responses, and block the propagation of β-amyloid (Aβ) fibrils. AChE-IN-80 possesses antioxidant activity and neuroprotective effects and can be used in the study of Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Autophagy; Reactive Oxygen Species (ROS)

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

NC(C1=CC(OC(N(C)CC)=O)=CC=C1)=S

Molecular Formula

C11H14N2O2S

Molecular Weight

238.31

References & Citations

[1]Sestito S, et al. Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules[J]. European Journal of Medicinal Chemistry, 2025, 283: 117175.