PDI-IN-4
PDI-IN-4 (Compound 14d) is an inhibitor of protein disulfide isomerase, with an IC50 value of 0.48 μM. PDI-IN-4 suppresses platelet aggregation and thrombus formation by attenuating GPIIb/IIIa activation without significantly causing cytotoxicity. PDI-IN-4 can be used in research on thrombosis[1].
Product Specifications
UNSPSC
12352005
Target
Integrin; PDI
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC=C(NC(C(C(F)(F)F)=C)=O)C=C1)C2=CC=CC=C2
Molecular Formula
C17H12F3NO2
Molecular Weight
319.28
References & Citations
[1]Chu JC, et al. Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase. Eur J Med Chem. 2025 Feb 5;283:117169.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-170655/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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