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PDI-IN-4

PDI-IN-4 (Compound 14d) is an inhibitor of protein disulfide isomerase, with an IC50 value of 0.48 μM. PDI-IN-4 suppresses platelet aggregation and thrombus formation by attenuating GPIIb/IIIa activation without significantly causing cytotoxicity. PDI-IN-4 can be used in research on thrombosis[1].

Product Specifications

UNSPSC

12352005

Target

Integrin; PDI

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=CC=C(NC(C(C(F)(F)F)=C)=O)C=C1)C2=CC=CC=C2

Molecular Formula

C17H12F3NO2

Molecular Weight

319.28

References & Citations

[1]Chu JC, et al. Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase. Eur J Med Chem. 2025 Feb 5;283:117169.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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