CDK4/6/HDAC-IN-1

CDK4/6/HDAC-IN-1 (Compound N14) is a dual-targeting inhibitor of CDK4/6 and HDAC (IC50: CDK4 = 7.23 nM, CDK6 = 13.20 nM, HDAC1 = 55.66 nM, HDAC6 = 48.38 nM) . CDK4/6/HDAC-IN-1 induces cell Apoptosis and G0/G1 phase arrest through HDAC-p21-CDK signaling pathway. CDK4/6/HDAC-IN-1 inhibits hepatocellular carcinoma[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; CDK; HDAC

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(NO)/C=C/C1=CC=C(NC(CN2CCN(C3=CC=C(NC4=NC=C5C(N(C6CCCC6)C(C(C(C)=O)=C5C)=O)=N4)N=C3)CC2)=O)C=C1

Molecular Formula

C35H39N9O5

Molecular Weight

665.74

References & Citations

[1]Niu Z, et al. Discovery of a novel CDK4/6 and HDAC dual-targeting agent for the treatment of hepatocellular carcinoma. Bioorg Chem. 2025 Jan;154:108080.