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SMase-IN-1

SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM) . SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration) . SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes[1].

Product Specifications

CAS Number

33017-85-5

UNSPSC

12352005

Target

Bacterial; Cholinesterase (ChE) ; Phospholipase

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C(C1=CC(Cl)=CC=C1N2)NC2=S

Molecular Formula

C8H5ClN2OS

Molecular Weight

212.66

References & Citations

[1]Ozturk OK, et al. Quinazoline derivatives as novel bacterial sphingomyelinase enzyme inhibitors. Bioorg Chem. 2025 Jan;154:108079.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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