SMase-IN-1
SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM) . SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration) . SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes[1].
Product Specifications
CAS Number
[33017-85-5]
UNSPSC
12352005
Target
Bacterial; Cholinesterase (ChE) ; Phospholipase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(C1=CC(Cl)=CC=C1N2)NC2=S
Molecular Formula
C8H5ClN2OS
Molecular Weight
212.66
References & Citations
[1]Ozturk OK, et al. Quinazoline derivatives as novel bacterial sphingomyelinase enzyme inhibitors. Bioorg Chem. 2025 Jan;154:108079.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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