TS-IN-5

TS-IN-5 (Compound 15) is a thymidylate synthase (TS) inhibitor. TS-IN-5 induces Apoptosis by modulating Bax, BCL-2, PI3K, and STAT1 proteins. TS-IN-5 shows antitumor effects against liver, breast and colon cancers[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; PI3K; STAT; Thymidylate Synthase

Related Pathways

Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1C(C2=NC3=CC=CC=C3S2)=CNC(N4CCN(C)CC4)=N1

Molecular Formula

C16H17N5OS

Molecular Weight

327.40

References & Citations

[1]Basiony EA, et al. Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents. Bioorg Chem. 2025 Jan;154:108066.