FLT3-IN-29
FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants) . FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) . FLT3-IN-29 displays antileukemic activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FLT3; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C)N1CCC(NC2=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C(C(N)=O)C=N2)CC1
Molecular Formula
C25H30N6O2
Molecular Weight
446.54
References & Citations
[1]Liu W, et al. Discovery of 3-amide-pyrimidine-based derivatives as potential fms-like tyrosine receptor kinase 3 (FLT3) inhibitors for treating acute myelogenous leukemia. Bioorg Med Chem Lett. 2024 Dec 19;117:130082.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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