MPGES-1/sEH-IN-1

MPGES-1/sEH-IN-1 (compound 1f) is an inhibitor of sEH with IC50 value of 5 μM. mPGES-1/sEH-IN-1 shows antitumor activity with IC50 value of 25 µM via inhibts mPGES‐1[1].

Product Specifications

UNSPSC

12352005

Target

Epoxide Hydrolase; Prostaglandin Receptor

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=CC(C(C2=CC=CC=C2)=O)=C(C)N1)NC3=CC(C(F)(F)F)=CC(N)=C3

Molecular Formula

C20H16F3N3O2

Molecular Weight

387.36

References & Citations

[1]Ester Colarusso, et al. 5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates. Arch Pharm (Weinheim) . 2025 Jan;358 (1) :e2400708.