MPGES-1/sEH-IN-1
MPGES-1/sEH-IN-1 (compound 1f) is an inhibitor of sEH with IC50 value of 5 μM. mPGES-1/sEH-IN-1 shows antitumor activity with IC50 value of 25 µM via inhibts mPGES‐1[1].
Product Specifications
UNSPSC
12352005
Target
Epoxide Hydrolase; Prostaglandin Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC(C(C2=CC=CC=C2)=O)=C(C)N1)NC3=CC(C(F)(F)F)=CC(N)=C3
Molecular Formula
C20H16F3N3O2
Molecular Weight
387.36
References & Citations
[1]Ester Colarusso, et al. 5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates. Arch Pharm (Weinheim) . 2025 Jan;358 (1) :e2400708.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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