α-Glucosidase-IN-79
α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC50 of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes[1].
Product Specifications
UNSPSC
12352100
Target
Glycosidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(NC1=C(C#N)C(CCC(C)C2)=C2S1)COC3=C(OC)C(OC)=CC(C=O)=C3
Molecular Formula
C21H22N2O5S
Molecular Weight
414.47
References & Citations
[1]Chen YT, et al. Design and synthesis of N- (3-cyanothiophen-2-yl) -2-phenoxyacetamide-based α-glucosidase inhibitors. Bioorg Med Chem Lett. 2025 Mar 1;117:130068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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