MMP-2 Inhibitor-4

MMP-2 Inhibitor-4 (Compound 5g) is an MMP-2 inhibitor with an IC50 of 152.62 nM. MMP-2 Inhibitor-4 can reduce the levels of MMP-2 in the K562 cell line through stable binding at the MMP-2 active site, and it demonstrates strong antiangiogenic effects in the ACHN cell line. MMP-2 Inhibitor-4 holds promise for research in chronic myeloid leukemia (CML) [1].

Product Specifications

UNSPSC

12352005

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C(NO)[C@H](NS(=O)(C1=CC=C(C)C=C1)=O)CCC(NCC2=CC=CC=C2)=O

Molecular Formula

C19H23N3O5S

Molecular Weight

405.47

References & Citations

[1]Das S, et al. Derivatives of D (-) -glutamine-based MMP-2 inhibitors as an effective remedy for the management of chronic myeloid leukemia-Part-III: Synthesis, biological screening and in silico binding interaction analysis. Bioorg Chem. 2025 Jan;154:108057.