PROTAC JNK1-targeted-1
PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader, with a DC50 of 10 nM. PROTAC JNK1-targeted-1 (PA2) decreases the level of Fibronectin protein. PROTAC JNK1-targeted-1 can be used for the research of pulmonary fibrosis[1]. (Pink: JNK1 inhibitor ; Black: linker (HY-40178) ; Blue: CRBN Ligand (HY-41547) )
Product Specifications
UNSPSC
12352005
Target
JNK; PROTACs
Related Pathways
MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C(NCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(NC5=NC=C(Br)C(NC6=CC=CC=C6C(N)=O)=N5)C=C4
Molecular Formula
C35H32BrN9O6
Molecular Weight
754.59
References & Citations
[1]Guo Y, et al. Design and synthesis of JNK1-targeted PROTACs and research on the activity. Bioorg Chem. 2025 Jan;154:108044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1
Frequently Asked Questions
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