PROTAC LZK degrader 1

PROTAC LZK degrader 1 (Compound 21A) is a PROTAC that targets the degradation of LZK (Leucine Zipper Kinase, encoded by MAP3K13) . PROTAC LZK degrader 1 (10 μM) promotes the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. PROTAC LZK degrader 1 can be used in cancer research. PROTAC LZK degrader 1 consists of an E3 ligase ligand (blue part, HY-112078), a target protein ligand (red part, HY-170596), and a linker (black part, HY-W019543) [1].

Product Specifications

CAS Number

[2763268-64-8]

UNSPSC

12352005

Target

C-Myc; MAP3K; MDM-2/p53; PROTACs

Related Pathways

Apoptosis; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

FC(CC1)(F)CN1C2=CC(C3CCN(C(CCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@@H](O)C4)=O)=O)=O)CC3)=CC(NC7=CC(C#N)=CC=N7)=N2

Molecular Formula

C51H64F2N10O5S

Molecular Weight

967.18

References & Citations

[1]Funk AL, et al. Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth. bioRxiv [Preprint]. 2024 Nov 20:2024.11.19.623840.