Antitumor agent-192
Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC50 of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts[1].
Product Specifications
UNSPSC
12352005
Target
Atg7; Autophagy
Related Pathways
Autophagy
Field of Research
Cancer
Smiles
CCN(CCCNCC1=NC(CNCCCN(CC)CC)=CC2=C1N(CCCC3=CC=CC=C3)C4=CC=CC=C24)CC
Molecular Formula
C36H54N6
Molecular Weight
570.85
References & Citations
[1]Ao J, et al. Design, synthesis and biological evaluation of novel β-carbolines as antitumor agents via targeting autophagy in colorectal cancer. Eur J Med Chem. 2025 Feb 5;283:117145.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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