ChREBPα/14-3-3 regulator-1
ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular gel that can stabilize the interaction of carbohydrate response element binding protein (ChREBP) with 14-3-3 proteins (EC50: 3.8 μM) . ChREBPα/14-3-3 regulator-1 effectively protects β cells from glucolipotoxicity and maintains cell function, and can be used in the study of type 2 diabetes[1].
Product Specifications
CAS Number
3067202-14-3
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
FC1=CC=CC(C(F)(F)CNC(COC2=C(P(O)(O)=O)C=CC=C2)=O)=C1
Molecular Formula
C16H15F3NO5P
Molecular Weight
389.26
References & Citations
[1]Katz LS, et al. Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. bioRxiv [Preprint]. 2024 Nov 17:2024.02.16.580675.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY434048 100 µg
APRIL (TNFSF13) (NM_001198624) Human Over-expression Lysate
Sign In for Pricing
View Details 
![PCNA Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3F3]](https://cdn.genprice.uk/products/937/68dd1b76061270361ea1a646/imageurl/ta800921am.webp)
TA800921AM 100 µL
PCNA Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3F3]
Sign In for Pricing
View Details