ChREBPα/14-3-3 regulator-1
ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular gel that can stabilize the interaction of carbohydrate response element binding protein (ChREBP) with 14-3-3 proteins (EC50: 3.8 μM) . ChREBPα/14-3-3 regulator-1 effectively protects β cells from glucolipotoxicity and maintains cell function, and can be used in the study of type 2 diabetes[1].
Product Specifications
CAS Number
3067202-14-3
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
FC1=CC=CC(C(F)(F)CNC(COC2=C(P(O)(O)=O)C=CC=C2)=O)=C1
Molecular Formula
C16H15F3NO5P
Molecular Weight
389.26
References & Citations
[1]Katz LS, et al. Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. bioRxiv [Preprint]. 2024 Nov 17:2024.02.16.580675.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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