ChREBPα/14-3-3 regulator-1

ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular gel that can stabilize the interaction of carbohydrate response element binding protein (ChREBP) with 14-3-3 proteins (EC50: 3.8 μM) . ChREBPα/14-3-3 regulator-1 effectively protects β cells from glucolipotoxicity and maintains cell function, and can be used in the study of type 2 diabetes[1].

Product Specifications

CAS Number

[3067202-14-3]

UNSPSC

12352005

Target

Molecular Glues

Related Pathways

PROTAC

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

FC1=CC=CC(C(F)(F)CNC(COC2=C(P(O)(O)=O)C=CC=C2)=O)=C1

Molecular Formula

C16H15F3NO5P

Molecular Weight

389.26

References & Citations

[1]Katz LS, et al. Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. bioRxiv [Preprint]. 2024 Nov 17:2024.02.16.580675.