P53 Activator 14
P53 Activator 14 (Compound 7A) is a derivative of Neratinib (HY-32721), that induces DNA damage, activates p53, and inhibits the proliferation of multi cancer cells (IC50=7.21 μM for HCT116 cell) . p53 Activator 14 inhibits the adhesion, migration and invasion of HCT116, arrests the cell cycle, and induces apoptosis. p53 Activator 14 inhibits angiogenesis and exhibits antitumor efficacy in chick chorioallantoic membrane (CAM) model[1].
Product Specifications
CAS Number
[2922588-44-9]
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(C1=CC=C(CN2CCN(CC2)C(C3CC3)=O)C=C1)NC4=CC=C(C(Cl)=C4)OCC5=NC=CC=C5
Molecular Formula
C28H29ClN4O3
Molecular Weight
505.01
References & Citations
[1]Liu ZY, et al., Neratinib derivative 7A induces apoptosis in colon cancer cells via the p53 pathway. Bioorg Med Chem Lett. 2025 Mar 1;117:130069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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