VEGFR-2-IN-61

VEGFR-2-IN-61 (Compound 7b) is an inhibitor for VEGFR-2 with an IC50 of 2.83 µM. VEGFR-2-IN-61 inhibits the proliferation of multi cancer cells (IC50 for MCF-7 is 2.12 μM) . VEGFR-2-IN-61 inhibits the cell migration, induces oxidative stress and apoptosis in MCF-7[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS) ; VEGFR

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

NC1=C(C(NC2=CC=C(C(C)C)C=C2)=O)C(C3=CNC4=C3C=CC=C4)=NN1C5=CC=CC=C5

Molecular Formula

C27H25N5O

Molecular Weight

435.52

References & Citations

[1]Valapil DG, et al., Development of 3-indolyl substituted phenyl pyrazolo-carboxamide hybrids as potential type II VEGFR-2 inhibitors and in vitro cytotoxicity studies. Bioorg Med Chem Lett. 2025 Mar 1;117:130070.