COX-2-IN-51
COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin.
Product Specifications
CAS Number
3064260-49-4
UNSPSC
12352005
Target
COX; NF-κB
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(OC(OCCC2=CSC=C2)(C(F)(F)F)C(C3=CC=C(OC)C=C3)=C4)C4=C1
Molecular Formula
C23H18F4O3S
Molecular Weight
450.45
References & Citations
[1]Cai N, et al. 2-Trifluoromethyl-2H-chromene ethers: The dual triumph of anti-inflammation and analgesia with minimal ulcer threat. Bioorg Chem. 2025 Jan;154:108050.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
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