HAChE-IN-10
HAChE-IN-10 (Compound ET11) is the inhibitor for human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. hAChE-IN-10 scavenges free radicals, and exhibits antioxidant activity. hAChE-IN-10 exhibits metal chelating activity, inhibits Cu2+-induced Aβ1-42 aggregation, reduces the formation of amyloid plaques, and exhibits neuroprotective activity. hAChE-IN-10 ameliorates the Scopolamine -induced cognitive impairment in mouse models[1].
Product Specifications
CAS Number
3058182-98-9
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=NN(C2=NC=C(C=C2)F)C(O)=C1)NCCCNC3=C(CCCC4)C4=NC5=C3C=CC(Cl)=C5
Molecular Formula
C25H24ClFN6O2
Molecular Weight
494.95
References & Citations
[1]Wang H, et al., Design, synthesis and biological evaluation of novel pyrazolinone derivatives as multifunctional ligands for the treatment of Alzheimer's disease. Bioorg Chem. 2025 Jan;154:108052.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
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