Topo I/II-IN-1
Topo I/II-IN-1 (compound 7t) is a potent Topo I and Topo II dual inhibitor. Topo I/II-IN-1 exhibits significant cytotoxicity against MCF-7 breast cancer cell lines with an IC50 of 7.45μM[1].
Product Specifications
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
C1(SC2=C3C(SC4=NC=CC=C4)=NC=N2)=C3CCCC1
Molecular Formula
C15H13N3S2
Molecular Weight
299.41
References & Citations
[1]Arora S, et al. Design, synthesis and anticancer evaluation of 4-Substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as dual topoisomerase I and II inhibitors. Bioorg Chem. 2025 Jan;154:108043.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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