Antioxidant agent-20

Antioxidant agent-20 (Compound 3d) has potent anti-inflammatory and antioxidant activity. Antioxidant agent-20 reduces reactive oxygen species (ROS) and apoptosis in a dose-dependent manner. Antioxidant agent-20 exhibits photoprotective effect against UVB-irradiated human skin keratinocytes (HaCaT) (IC50=5.13 µM) via activation of Nrf2/HO-1 signaling and inhibition of NF-κB pathway[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Smiles

CC1=C2C(CCC(C(OC3CCC3)=O)(C)O2)=C(C)C(O)=C1C

Molecular Formula

C18H24O4

Molecular Weight

304.38

References & Citations

[1]Zhao J, et al. Trolox derivatives: Synthesis, structure-activity relationship and promote wound healing by regulating oxidative stress and inflammation. Bioorg Chem. 2025 Jan;154:108045.