SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent SIRT2 inhibitor. SIRT2-IN-17 reduces the expression of α-SMA and p-Smad2/3[1].
Product Specifications
UNSPSC
12352005
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC=NC=C1C=O)/C(C#N)=C/C2=CC(C3=C(C=CC=C4)C4=CC=C3)=CS2
Molecular Formula
C24H15N3O2S
Molecular Weight
409.46
References & Citations
[1]Zhang Z, et al. Design, synthesis, and biological evaluation of novel 3-naphthylthiophene derivatives as potent SIRT2 inhibitors for the treatment of myocardial fibrosis. Bioorg Chem. 2025 Jan;154:108033.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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