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SIRT2-IN-17

SIRT2-IN-17 (compound Z18) is a potent SIRT2 inhibitor. SIRT2-IN-17 reduces the expression of α-SMA and p-Smad2/3[1].

Product Specifications

UNSPSC

12352005

Target

Sirtuin

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(NC1=CC=NC=C1C=O)/C(C#N)=C/C2=CC(C3=C(C=CC=C4)C4=CC=C3)=CS2

Molecular Formula

C24H15N3O2S

Molecular Weight

409.46

References & Citations

[1]Zhang Z, et al. Design, synthesis, and biological evaluation of novel 3-naphthylthiophene derivatives as potent SIRT2 inhibitors for the treatment of myocardial fibrosis. Bioorg Chem. 2025 Jan;154:108033.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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