PKM2-IN-8
PKM2-IN-8 (Compound 9b) is a pyruvate kinase M2 (PKM2) inhibitor (IC50 = 0.31 μM) . PKM2-IN-8 has potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 can induce early apoptosis and reduce lactate levels. PKM2-IN-8 can be used for the research of glioblastoma[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Pyruvate Kinase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(CN1N=C(C2=CC=C(C=CC=C3)C3=C2)N=N1)C4=CN=C5N4C=CC=N5
Molecular Formula
C19H13N7O
Molecular Weight
355.35
References & Citations
[1]Chowdhury MG, et al. Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells. Bioorg Chem. 2025 Jan;154:108029.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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