CQ627

CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Molecular Glues; Ser/Thr Kinase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC1=CC=C(C(/C=C/C(N2CCN(C3=C(C(F)(F)F)C=C(N4N=NC5=C4C6=CC(C7=CC=C(OC)N=C7)=CC=C6NC5=O)C=C3)CC2)=O)=O)C=C1

Molecular Formula

C36H27F4N7O4

Molecular Weight

697.64

References & Citations

[1]Ma H, et al. Discovery of the first examples of right open reading frame kinase 2 (RIOK2) molecular glue degraders. Eur J Med Chem. 2025 Feb 5;283:117166.