PB01
PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively inhibits high glucose-induced ROS production and mitochondrial superoxide formation while significantly reducing cellular DPP-4 expression. PB01 can also significantly lower blood glucose levels in diabetic mice. Additionally, PB01 demonstrates good safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds potential for research in the field of diabetes[1].
Product Specifications
CAS Number
368434-78-0
UNSPSC
12352005
Target
Dipeptidyl Peptidase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Metabolic Disease
Smiles
O=C1C2=C(N(C)C(N1C)=O)N=C(N3CCOCC3)N2CC4=CC=CC=C4
Molecular Formula
C18H21N5O3
Molecular Weight
355.39
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4
Frequently Asked Questions
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