PB01

PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively inhibits high glucose-induced ROS production and mitochondrial superoxide formation while significantly reducing cellular DPP-4 expression. PB01 can also significantly lower blood glucose levels in diabetic mice. Additionally, PB01 demonstrates good safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds potential for research in the field of diabetes[1].

Product Specifications

CAS Number

[368434-78-0]

UNSPSC

12352005

Target

Dipeptidyl Peptidase; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Smiles

O=C1C2=C(N(C)C(N1C)=O)N=C(N3CCOCC3)N2CC4=CC=CC=C4

Molecular Formula

C18H21N5O3

Molecular Weight

355.39

References & Citations

[1]Bisht P, et al. Design and synthesis of novel 3,7-dihydro-1H-purine-2,6-diones as DPP-4 inhibitors: An in silico, in vitro and in vivo approach. Eur J Med Chem. 2025 Feb 5;283:117160.