PFM046
PFM046 is the antagonist for liver X receptor (LXR), that inhibits the activation of LXRα and LXRβ with IC50 of 2.04 μM and 1.58 μM. PFM046 inhibits the expression of SCD1 and FASN, upregulates the expression of ABCA1, and exhibits antitumor efficacy in mouse models[1].
Product Specifications
CAS Number
3053859-57-4
UNSPSC
12352005
Target
Fatty Acid Synthase (FASN) ; LXR; Stearoyl-CoA Desaturase (SCD)
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)[C@H](CC3=CC=CC=C3)O)([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC1
Molecular Formula
C29H42O2
Molecular Weight
422.64
References & Citations
[1]Pontini L, et al., Discovery of 22 (S) -23-phenyl-24-norchol-5-en-3β,22-diol (PFM046) as the first-in-class, steroidal, non-sulfated Liver X Receptor antagonist with anticancer activity. Eur J Med Chem. 2025 Feb 5;283:117136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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