DNA gyrase/Topo IV-IN-1

DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV, exhibiting antibacterial activity. For Escherichia coli and methicillin-resistant Staphylococcus aureus DNA gyrases, DNA gyrase/Topo IV-IN-1 has an IC50 of 11 and 17 nM respectively, and for topoisomerase IV of Escherichia coli and methicillin-resistant Staphylococcus aureus, the IC50 values are 83 and 21 nM respectively. DNA gyrase/Topo IV-IN-1 can be used for research in the field of anti-infection[1].

Product Specifications

UNSPSC

12352005

Target

Antibiotic; Bacterial; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O=C1C(C)(C)C(C([C@H](C(C)C)C(C(OCCN2CCCC2)=C([C@H](C(C)C)C(C(C(C)(C)C(C3(C)C)=O)=O)=C3O4)C4=C5C(C(C)C)=O)=C5O6)=C6C1(C)C)=O

Molecular Formula

C44H59NO8

Molecular Weight

729.94

References & Citations

[1]Yang H, et al. Discovery, synthesis, and antibacterial activity of novel myrtucommulone analogs as inhibitors of DNA gyrase and topoisomerase IV. Eur J Med Chem. 2025 Feb 5;283:117138.