CHD-1

CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo[1].

Product Specifications

CAS Number

[3041166-70-2]

UNSPSC

12352005

Target

Apoptosis; Mitophagy

Related Pathways

Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Smiles

FC1=CC(C(/C=C/C2=CC=CC([N+]([O-])=O)=C2)=O)=CC=C1OC

Molecular Formula

C16H12FNO4

Molecular Weight

301.27

References & Citations

[1]Wang F, et al. Hypoxia-selective prodrug restrains tumor cells through triggering mitophagy and inducing apoptosis. Eur J Med Chem. 2025 Feb 5;283:117155.