Tubulin polymerization-IN-72

Tubulin polymerization-IN-72 (Compound 4a4) is an anticancer agent that acts as a tubulin polymerization inhibitor. It inhibits tubulin polymerization by binding to the colchicine site, leading to cancer cell arrest in the G2/M phase and inducing their apoptosis (Apoptosis) . Tubulin polymerization-IN-72 has an IC50 of 0.4-2.7 nM against cancer cells.

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

COC1=CC(CCC2)=C(C=C1)N2C3=NC(NC)=NC4=CC=C(F)C=C43

Molecular Formula

C19H19FN4O

Molecular Weight

338.38

References & Citations

[1]Lai Q, et al. Design, synthesis, and antitumor evaluation of quinazoline-4-tetrahydroquinoline chemotypes as novel tubulin polymerization inhibitors targeting the colchicine site. Eur J Med Chem. 2025 Feb 5;283:117139.