Tubulin polymerization-IN-72
Tubulin polymerization-IN-72 (Compound 4a4) is an anticancer agent that acts as a tubulin polymerization inhibitor. It inhibits tubulin polymerization by binding to the colchicine site, leading to cancer cell arrest in the G2/M phase and inducing their apoptosis (Apoptosis) . Tubulin polymerization-IN-72 has an IC50 of 0.4-2.7 nM against cancer cells.
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
COC1=CC(CCC2)=C(C=C1)N2C3=NC(NC)=NC4=CC=C(F)C=C43
Molecular Formula
C19H19FN4O
Molecular Weight
338.38
References & Citations
[1]Lai Q, et al. Design, synthesis, and antitumor evaluation of quinazoline-4-tetrahydroquinoline chemotypes as novel tubulin polymerization inhibitors targeting the colchicine site. Eur J Med Chem. 2025 Feb 5;283:117139.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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