STEP-IN-1
STEP-IN-1 (Compound 14b) is a potent and selective STEP inhibitor with an IC50 of 5.27 μM. STEP-IN-1 has a neuroprotective effect, which can protect nerve cells from glutamate-induced toxicity, reduce cellular ROS accumulation, and inhibit apoptosis. STEP-IN-1 can be used in the study of neurodegenerative diseases[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Neurological Disease
Smiles
O=C(/C1=C/C2=CC=C(O2)C3=CC=C(C=C3Cl)C(O)=O)C4=C(C=CC=C4[N+]([O-])=O)C1=O
Molecular Formula
C21H10ClNO7
Molecular Weight
423.76
References & Citations
[1]Jiang C, et al. Design and synthesis of novel benzoic acid derivatives as striatal-enriched protein tyrosine phosphatase (STEP) inhibitors with neuroprotective properties. Eur J Med Chem. 2025 Feb 5;283:117135.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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