AChE/BuChE-IN-6

AChE/BuChE-IN-6 (Compound 11f) is an inhibitor of AChE and BuChE, with IC50 values of 1.24 and 1.85 μg/mL, respectively. AChE/BuChE-IN-6 also exhibits strong DPPH free radical scavenging activity (IC50 = 3.15 μg/mL) . In vivo toxicity studies indicate that AChE/BuChE-IN-6 is safe, showing no significant differences in blood and biochemical markers compared to the control group after long-term administration, and no abnormalities were observed in liver and kidney tissues. AChE/BuChE-IN-6 holds promise for research into Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(NC1=CC=C(Cl)C=C1)COC2=CC=C(O)C(C3=C(C4=CC=C(C)C=C4)NN=C3)=C2

Molecular Formula

C24H20ClN3O3

Molecular Weight

433.89

References & Citations

[1]Elkotamy MS, et al. Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management. Eur J Med Chem. 2025 Feb 5;283:117158.