EGFR-IN-141

EGFR-IN-141 (Compound 8I) is the inhibitor for EGFR with an IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cell A549 with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor efficacy[1].

Product Specifications

CAS Number

[3054263-27-0]

UNSPSC

12352005

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1C2=C(N=CN1CC3=NN=C(N3N)SCC(NC4=NC5=C(S4)C=C(F)C=C5)=O)C=CC=C2

Molecular Formula

C20H15FN8O2S2

Molecular Weight

482.51

References & Citations

[1]Evren A E, et al. Pharmacophore‐Based Modeling, Synthesis, and Biological Evaluation of Novel Quinazoline/Quinoline Derivatives: Discovery of EGFR Inhibitors with Low Nanomolar Activity[J]. Advanced Theory and Simulations, 2024: 2400811.