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FW-1

FW-1 is a type I inhibitor for FLT3 with IC50 of ca. 1 μM. FW-1 exhibits cytotoxicity in FLT3 mutated AML cell. FW-1 arrests the cell cycle at G0/G1 phase, and induces apoptosis in cell MV4-11 and MOLM-13[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; FLT3

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

NC1=NOC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=CC(NC5=CC=CC=C5)=C21

Molecular Formula

C24H27N7O

Molecular Weight

429.52

References & Citations

[1]Yang J, et al., Design, Synthesis, and Biological Activities Evaluation of Type I FLT3 Inhibitors for the Treatment of Acute Myeloid Leukemia. Drug Dev Res. 2024 Dec;85 (8) :e70022.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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