CA IX/VEGFR-2-IN-3
CA IX/VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. CA IX/VEGFR-2-IN-3 exhibits anticancer activity, inhibiting the growth of MCF-7 breast cancer cells (with an IC50 of 22.33 μM) and mouse fibroblast cell line 3T3 (where cell viability is less than 40% at a concentration of 100 μM) . CA IX/VEGFR-2-IN-3 can be used for research in the field of cancer treatment[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase; VEGFR
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C)C(S(=O)(N)=O)=C1)CN(C/2=O)C(SC2=C/C3=CC=C(Cl)C=C3)=O
Molecular Formula
C19H16ClN3O5S2
Molecular Weight
465.93
References & Citations
[1]Zengin M, et al. Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR-2 Inhibitors Based on the Benzenesulfonamide-Bearing 4-Thiazolidinones/2,4-Thiazolidinediones Scaffold. Drug Dev Res. 2024 Dec;85 (8) :e70030.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; VEGFR2/KDR/Flk-1
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