CA IX/VEGFR-2-IN-3

CA IX/VEGFR-2-IN-3 (Compound 6i) is an inhibitor of Carbonic Anhydrase IX and VEGFR-2, with IC50 values of 41 and 48 nM, respectively. CA IX/VEGFR-2-IN-3 exhibits anticancer activity, inhibiting the growth of MCF-7 breast cancer cells (with an IC50 of 22.33 μM) and mouse fibroblast cell line 3T3 (where cell viability is less than 40% at a concentration of 100 μM) . CA IX/VEGFR-2-IN-3 can be used for research in the field of cancer treatment[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase; VEGFR

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(C)C(S(=O)(N)=O)=C1)CN(C/2=O)C(SC2=C/C3=CC=C(Cl)C=C3)=O

Molecular Formula

C19H16ClN3O5S2

Molecular Weight

465.93

References & Citations

[1]Zengin M, et al. Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR-2 Inhibitors Based on the Benzenesulfonamide-Bearing 4-Thiazolidinones/2,4-Thiazolidinediones Scaffold. Drug Dev Res. 2024 Dec;85 (8) :e70030.