KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is the inhibitor for mutant RAS protein KRASG12C with an IC50 of 4.36 nM. KRAS G12C inhibitor 69 inhibits the ERK phosphorylation in NCI-H358 and MIA-PACA-2 with an IC50 of 12 nM and 7 nM. KRAS G12C inhibitor 69 inhibits the proliferation of cancer cell NCI-H358 and MIA-PACA-2 with IC50 of 3.15 nM and 2.33 nM[1].
Product Specifications
UNSPSC
12352005
Target
ERK; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
FC1=C(C2=C(F)C(N=C(OC[C@@]34N(CCC4)C[C@H](F)C3)N=C5N6CCN(C(C=C)=O)CC6)=C5C=C2Cl)C(O)=CC=C1
Molecular Formula
C29H29ClF3N5O3
Molecular Weight
588.02
References & Citations
[1]Liu N, et al. Discovery of Quinazoline Derivatives as Potent KRASG12C Inhibitors[J]. ChemistrySelect, 2024, 9 (39) : e202402267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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