DNA polymerase-IN-6

DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, and inhibits HCMV, HSV-1, HSV-2 and EBV with EC50s of 0.33, 1.9, 0.76 and 0.066 µM, respectively[1].

Product Specifications

CAS Number

[2701561-91-1]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Filovirus; HSV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

NCCN1CCN(C2=NC(C=C(C(NCC3=CC=C(Cl)C=C3)=O)C(N4CC(N5CC(C)(F)C5)=O)=O)=C4N=C2)C1=O

Molecular Formula

C26H28ClFN8O4

Molecular Weight

571.00

References & Citations

[1]Bai B, et al., Discovery of Novel Pyrido[2,3-b]Pyrazine Human Cytomegalovirus Polymerase Inhibitors with Broad Spectrum Antiherpetic Activity and Reduced hERG Inhibition. ChemMedChem. 2024 Dec 10:e202400629.