RIPK1-IN-28
RIPK1-IN-28 (compound 13) is an orally active RIPK1 inhibitor. RIPK1-IN-28 inhibits human I2.1 and Hepa1‐6 cells with IC50s of 0.4 and 1.2 nM, respectively[1].
Product Specifications
CAS Number
[2968509-28-4]
UNSPSC
12352005
Target
RIP kinase
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CN1C2=CC(C#CC3CC3)=CC=C2OC[C@@H](C1=O)NC(C4=NN(C5=CC=CC=C5)C(C)=CC4=O)=O
Molecular Formula
C27H24N4O4
Molecular Weight
468.50
References & Citations
[1]An Y, et al. Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors. Arch Pharm (Weinheim) . 2025 Jan;358 (1) :e2400594.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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