Dual Galectin-3/EGFR-IN-1
Dual Galectin-3/EGFR-IN-1 (Compound 29) is the dual inhibitor for Galectin-3 and EGFR with the KD of 52.29 μM and 3.31 μM. Dual Galectin-3/EGFR-IN-1 inhibits TGF-β-induced hepatic stellate cell (HSCs) activation, induces apoptosis in LX-2 cell, and exhibits anti-liver fibrotic efficacy[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR; Galectin
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
COCCOC1=CC2=C(N=CN=C2NC3=CC(C4=CN(CCO[C@H]5O[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]5NC(C)=O)N=N4)=CC=C3)C=C1OCCOC
Molecular Formula
C32H41N7O10
Molecular Weight
683.71
References & Citations
[1]Liu S, et al., Design and Synthesis of Dual Galectin-3 and EGFR Inhibitors Against Liver Fibrosis. Chem Asian J. 2025 Jan 17;20 (2) :e202401078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; Galectin-3
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