FUT8-IN-1

FUT8-IN-1 (Compound 37) is an inhibitor for α-1,6-fucosyltransferase (FUT8) with an KD of 49 nM and an IC50 of ca. 50 µM. FUT8-IN-1 generates a highly active naphthoquinone imine intermediate in the presence of FUT8, and inhibits the enzymatic activity of FUT8[1].

Product Specifications

CAS Number

[3073704-71-6]

UNSPSC

12352005

Target

Glucosylceramide Synthase (GCS)

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

ClC1=CC=C2C(C=CC(O)=C2CN3CCN(CC)CC3C4=CC=CC=C4)=C1

Molecular Formula

C23H25ClN2O

Molecular Weight

380.91

References & Citations

[1]Manabe Y, et al. Development of a FUT8 Inhibitor with Cellular Inhibitory Properties[J]. Angewandte Chemie International Edition, 2024, 63 (52) : e202414682.