FUT8-IN-1
FUT8-IN-1 (Compound 37) is an inhibitor for α-1,6-fucosyltransferase (FUT8) with an KD of 49 nM and an IC50 of ca. 50 µM. FUT8-IN-1 generates a highly active naphthoquinone imine intermediate in the presence of FUT8, and inhibits the enzymatic activity of FUT8[1].
Product Specifications
CAS Number
[3073704-71-6]
UNSPSC
12352005
Target
Glucosylceramide Synthase (GCS)
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
ClC1=CC=C2C(C=CC(O)=C2CN3CCN(CC)CC3C4=CC=CC=C4)=C1
Molecular Formula
C23H25ClN2O
Molecular Weight
380.91
References & Citations
[1]Manabe Y, et al. Development of a FUT8 Inhibitor with Cellular Inhibitory Properties[J]. Angewandte Chemie International Edition, 2024, 63 (52) : e202414682.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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