NOX4-IN-1

NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F[1].

Product Specifications

UNSPSC

12352005

Target

NADPH Oxidase; Reactive Oxygen Species (ROS) ; TGF-beta/Smad

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Inflammation/Immunology

Smiles

CN1C2=C(C=C(C3=C(Cl)C=C(OC(NC(C4=CC=CC(C#N)=C4)=O)=CC5=O)C5=C3)C=C2)C=C1

Molecular Formula

C26H16ClN3O3

Molecular Weight

453.88

References & Citations

[1]Wu S, et al., Chromone Derivatives as a Novel NOX4 Inhibitor: Design, Synthesis, and Regulation of ROS in Renal Fibroblast. Chem Biol Drug Des. 2024 Nov;104 (5) :e70015.