NOX4-IN-1
NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F[1].
Product Specifications
UNSPSC
12352005
Target
NADPH Oxidase; Reactive Oxygen Species (ROS) ; TGF-beta/Smad
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
CN1C2=C(C=C(C3=C(Cl)C=C(OC(NC(C4=CC=CC(C#N)=C4)=O)=CC5=O)C5=C3)C=C2)C=C1
Molecular Formula
C26H16ClN3O3
Molecular Weight
453.88
References & Citations
[1]Wu S, et al., Chromone Derivatives as a Novel NOX4 Inhibitor: Design, Synthesis, and Regulation of ROS in Renal Fibroblast. Chem Biol Drug Des. 2024 Nov;104 (5) :e70015.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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